Importantly, EL-NB and EL-B were able to effectively classify B and NB patients defined by IHC as either HER2-negative/equivocal (AUC = 0.73, Supplementary Fig. 5A) or HER2-positive cancers (AUC = 0.84, Supplementary Fig. 5B). This evidence concerns the gene ERBB2 and cancer.