Notably, while acetylation of NF-κB was increased by TNF-α stimulation, levels of phosphorylated NF-κB, I-κB, and NF-κB were not altered in DKD epithelial cells, suggesting that the inflammatory phenotypes were also partially dependent on the SIRT1 pathway (Fig. 7d). The gene discussed is SIRT1; the disease is diabetic kidney disease.