Phenotypic characterization of GPR50ko/MMTV/Neu mice showed a tendency for decreased survival (p = 0.056; Kaplan–Meier survival curve with log-rank Mantel–Cox test; Supplementary Fig. 6a), no impact on tumor onset (Supplementary Fig. 6d) but a drastic reduction of overall survival after tumor onset from 70 to 28 days was observed (Fig. 6a, b). This evidence concerns the gene ERBB2 and neoplasm.