To clarify the role of TβRII in the context of the TGFβ-insensitive GPR50/TβRI complex, we used gastric carcinoma SNU638 cells, which do not respond to TGFβ as they are devoid of TβRII expression30 (Supplementary Fig. 4a). The gene discussed is TGFBR2; the disease is gastric carcinoma.