SERPINF1 and neoplasm: Pigment epithelium-derived factor (PEDF, a.k.a. SERPINF1), a multifunctional, non-inhibitory member of the serine protease inhibitor (SERPIN) superfamily, is a potent neurotrophic factor acting in the eye and spinal cord, is a potent inhibitor of angiogenesis32, and acts as a tumor suppressor via binding to high affinity ligands and cell-surface receptors33.