After meta-analysis, rs75444904 SNP was significantly associated with a 77% increased risk for DKD progression after adjustment for age, sex, principle components, BMI, HbA1c, diabetes duration, systolic blood pressure, HDL-C, LDL-C, TG, eGFR, uACR and intake of insulin and RAS antagonist (OR = 1.77, 95% CI 1.32–2.23, p = 0.014) (Table 3, Supplementary Table S8). The gene discussed is INS; the disease is diabetes mellitus.