SLC16A1 and neoplasm: Using spheroids obtained from 3D FaDu cell cultures (more prone to generate spheroids than SiHa cells) we found that either MCT or MPC inhibition reduced the growth of tumor spheroids (Fig. 5a, b) but while cytostatic effects were obtained with AR-C155858, inhibition of mitochondrial pyruvate transport by 7ACC2 led to cytotoxic effects.