The obtained interaction network for the 19 proteins is shown in Fig 4D. This included KLF5 and SOS1 proteins, which are both homologs of known cancer driver genes (Dataset EV2), as well as transcriptional regulators CARM1 and ZBTB7A, and signaling regulators RHPN2 and GPX1. The gene discussed is ZBTB7A; the disease is cancer.