NFKB1 and central precocious puberty: We found that cocaine treatment markedly increased the expression of phospho-NF-κB-p65 both in the cytoplasm and nucleus of cocaine-induced CPP mice (Fig. 6a; t(4) = 3.410, *p < 0.05; Fig. 6b; t(4) = 5.964, **p < 0.01), which is consistent with previous studies.