The hazard ratio (model 3) for the association between osteopontin and CHD and CVD mortality was HRper 5 ng/ml 1.11 (0.97–1.28) and HRper 5 ng/ml 1.13 (0.95–1.33) for CHD incidence and CVD mortality respectively. The gene discussed is SPP1; the disease is coronary artery disorder.