APOE and atherosclerosis: Previous studies have shown that oxidative stress and inflammation play a critical role in the development of atherosclerosis.31, 32 A high‐fat diet has been shown to increase oxidative stress and arterial inflammation.33 Other studies have shown that FA has antioxidant7 and anti‐inflammatory properties.11 Carnicer et al demonstrated that FA supplementation can decrease atherosclerotic lesions in apoprotein (Apo)E‐deficient mice independent of plasma homocysteine and cholesterol levels.