Therefore, the mTOR signalling pathway has been identified as a therapeutic target.39, 40 Rapamycin and its analogues are widely used in preventing restenosis and suppressing atherosclerosis.41 Jahrling et al21 showed that rapamycin‐mediated mTOR attenuation decreased the atherosclerosis lesion area in high‐fat‐fed LDLR−/− mice. This evidence concerns the gene LDLR and atherosclerosis.