APOE and atherosclerosis: Moreover, it is well known that the use of the mTOR inhibitor, rapamycin, also reduces oxidative stress, modulates the inflammatory response and attenuates atherosclerotic lesion progression in ApoE−/− mice.34 Our findings confirm those of these previous studies and again demonstrate that FA prevents oxidative stress, decreases the levels of inflammatory cytokines and ameliorates the progression of atherosclerosis in high‐fat‐fed LDLR−/− mice.