RPS6KB1 and atherosclerosis: In the present study, we demonstrated that FA could suppress the mTOR/p70S6K signal pathway and inhibit VSMC dedifferentiation in vivo, and we found that FA through inhibiting the mTOR pathway inhibits VSMC dedifferentiation, results consistent with our previous in vitro studies.45 However, the regulation of the mTOR/p70S6K signalling pathway and its effects on the phenotypic switching of VSMCs in atherosclerosis is still not fully understood.