In SLE, IL‐6, MCP‐1, IFN‐γ and TNF‐α promotes the progression of this disease.39, 40, 41, 42 On the contrary, IL‐10 and TGF‐β are anti‐inflammatory cytokines, which are related to SLE recovery.14, 43 As shown in Figure 2A, ARA290 treatment significantly decreased the serum levels of IL‐6, MCP‐1 and TNF‐α, and increased the serum levels of TGF‐β, suggesting an inflammation suppressing role of ARA290 in SLE. This evidence concerns the gene TNF and systemic lupus erythematosus.