The blocking of TNF‐α function in patients with SLE decreased the disease severity.8, 9 In addition, in humans and mice with lupus nephritis, IL‐6 promoted autoantibody production and was correlated with the SLE activity.10, 11 Therefore, the restrain of the inflammatory response could facilitate the improvement of SLE. This evidence concerns the gene IL6 and systemic lupus erythematosus.