TNF and systemic lupus erythematosus: In the current study, our in vivo and in vitro studies showed that ARA290 ameliorated inflammatory response in SLE mice and, notably, suppressed the expression of TNF‐α, IL‐6, iNOS and MCP‐1 in macrophages, which suggested that ARA290 might alleviated the symptoms of SLE via regulating macrophage inflammatory response; however, the definite mechanism between ARA290 and macrophage inflammatory response needs further investigation.