One of the most reliable criteria for SLE is an increase in antinuclear antigen autoantibodies in the serum.38 A significant decrease in the serum concentrations of anti‐dsDNA antibodies (ADA) and antinuclear antibodies (ANA) was observed in ARA290‐treated SLE mice compared to the control mice (Figure 1B). This evidence concerns the gene ADA and systemic lupus erythematosus.