BTG3 and systemic lupus erythematosus: One of the most reliable criteria for SLE is an increase in antinuclear antigen autoantibodies in the serum.38 A significant decrease in the serum concentrations of anti‐dsDNA antibodies (ADA) and antinuclear antibodies (ANA) was observed in ARA290‐treated SLE mice compared to the control mice (Figure 1B).