EGFR and non-small cell lung carcinoma: To investigate whether and how cigarette smoke influenced the sensitivity to EGFR TKIs in NSCLC, we first established CSE‐treated clones from wtEGFR‐expressing NCI‐H292 and mutEGFR‐expressing HCC827 and PC9 cells by chronic exposure to 1% CSE or 5% CSE for at least 2 months.