EGFR and cancer: In addition to genetic alternations associated with tumorigenesis, cigarette smoking behavior was also associated with the insensitivity to EGFR TKIs and poor progression‐free survival (PFS) in different types of cancer patients with EGFR overexpression (Gazdar, 2009; Lee et al., 2006; Miller et al., 2004; Takano et al., 2004).