As Tcm cells are uncommitted to any particular effector cytokine production, they can differentiate under the influence of the cytokine milieu triggered by the challenge infection.57 Vaccines that drive the generation of Tcm cells may provide less immediate protection than those designed to induce Trm cells; however, they offer an adaptable pool of memory CD4 T‐cells that can protect via multiple pathways. Here, CD4 is linked to infection.