AGO2 and infection: In T. annulata-infected macrophages miR-126-5p levels therefore do not depend on the degree of EGFL7 expression [48], nor on the amount of precursor miR-126, rather infection impacts on the capacity of AGO2 to load miR-126-5p, where it’s protected from degradation, while miR-126-3p is not loaded and is consequently degraded.