XCR1+ cDC1 have been shown to play an important role for intestinal T cell homeostasis because mice with constitutive ablation of XCR1+ cDCs have greatly diminished levels of intraepithelial lymphocytes (IEL) and lamina propria T cells, which goes along with an increased susceptibility to DSS-induced colitis [204]. The gene discussed is XCR1; the disease is colitis.