APC and neoplasm: The Apc floxed allele has also been used to illustrate that gastric tumourigenesis can be triggered upon deregulation of Wnt signalling, however, Mist1Cre;Apcfl/fl mice only develop tumours in the antrum [241], despite robust recombination and deregulation of Wnt signalling in both the corpus and antrum [32], highlighting that the antrum is more sensitive to Wnt signalling.