APC and colorectal carcinoma: Near the turn of the 20th century, several groups mapped and functionally linked APC (previously discussed), located on chromosome 5q21, to sporadic colorectal cancer (CRC) and familial adenomatous polyposis (FAP), the latter being an autosomal dominant condition that drives the formation of hundreds to thousands of small benign tumours in the large intestine, which can progress to cancer [81,82].