CREB3L3 and Hyperglycemia: Consistent with the results in 2-AG-treated HepG2 cells, GN treatment reversed tunicamycin-induced expression of gluconeogenesis genes including CREBH, PEPCK, and G6Pase. Taken together, these results indicate that GN inhibits CB1R-induced gluconeogenesis via suppression of ER stress, which might contribute to improvement of hyperglycemia.