Moreover, hepatic CB1R activation stimulates the lipogenesis transcription factor, sterol regulatory element-binding transcription factor 1c (SREBP1c), and results in increased TG accumulation by upregulating the expression of its downstream lipogenesis genes, including fatty acid synthase (FAS), stearoyl-Coenzyme A desaturase 1 (SCD1), and acetyl-CoA carboxylase (ACC), which contributes to insulin resistance and steatosis [6]. This evidence concerns the gene CNR1 and Insulin resistance.