In 2017 the FDA approved the use of the CD19-targeting CAR T-cell therapy tisagenlecleucel (Kymriah, Novartis, Basel, Switzerland) for treatment of patients of 25 years or under with ALL and axicabtagene ciloleucel (Yescarta, Kite Pharma, Los Angeles, CA, USA) for adults with ALL. This evidence concerns the gene CD19 and acute lymphoblastic leukemia.