Conversely, a more recent study shows that global heterozygous and adipose-specific ATX deficiencies protect mice on a C57Bl6 background from diet-induced obesity, while adipose-specific ATX overexpression driven from the FABP4 promoter enhances adiposity following high-fat diet feeding [31]. Here, ENPP2 is linked to obesity due to melanocortin 4 receptor deficiency.