HMBS and frontotemporal dementia: Finally, there is another distinction based on the neuropathological alterations that affect mainly the frontal and temporal lobes, named “frontotemporal lobar degeneration” (FTLD), where specific protein aggregates determine different types of FTD termed: FTLD-tau (tau protein), FTLD-TDP (transactive response of DNA-binding protein), FTLD-FET (FUS, EWS, and TAF15 protein family), and FTLD-UPS (Ubiquitin Proteasome System) [37,46,47].