Further evidence of direct tau and α-syn involvement in these pathologies is supported by the induction of α-syn as related to tau hyperphosphorylation, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of parkinsonism in mice [77] and co-localization of phosphorylated tau and α-syn in both NFT and LBs [87]. The gene discussed is MAPT; the disease is Parkinson disease.