Aversa et al. reported that HMB administration in vivo Wistar rats model of cancer cachexia markedly increased the phosphorylated p70S6K and phosphorylated mTOR, and remarkable increased phosphorylated 4-E-BP1 was alleviated in rats received an i.p. inoculum of AH-130 cells by HMB treatment [68]. The gene discussed is MTOR; the disease is cancer.