Similarly, a dataset derived from a mouse model of Coffin-Lowry syndrome (OMIM # 303600), a syndromic form of intellectual disability caused by loss-of-function mutations in the RPS6KA3 gene which encodes RSK2, also showed that nearly 24% (22 genes) of the genes that are downregulated in Rsk2-KO mice are upregulated by forniceal DBS (Figure 7A). Here, RPS6KA3 is linked to Coffin-Lowry syndrome.