TNFSF10 and breast carcinoma: Previous studies have indicated that orlistat treatment resulted in G1/S stage arrest of cell proliferation and decreased DNA synthesis followed by receptor‐mediated apoptosis via caspase‐8 activation.39 Pre‐treatment of MCF‐7 mammary carcinoma cells with orlistat for 24 hr also sensitised the cells to TRAIL‐induced apoptosis.