CP and neoplasm: Reductions in glutamate, glutamine, glutathione, carnitine, creatine, β‐hydroxybutyrate and ADP were found in tumours treated with the combination of orlistat and cisplatin (ORL/CP D2), indicating that fatty‐acid β‐oxidation and glutamine metabolism are compromised in these tumours which could result in reduced nucleotide and glutathione production.