The same study has also shown that orlistat administration in vivo not only resulted in reduced FASN expression and activity, but also reduced the expression of multidrug resistance protein (MDR) and multidrug resistance associated protein‐1 (MRP‐1).48 Thus, the study suggested that one of the mechanisms by which orlistat makes tumour cells susceptible to cisplatin cytotoxicity is by inhibiting multidrug resistance regulating molecules. This evidence concerns the gene FASN and neoplasm.