Glutamate (p = 0.04), glutamine (p = 0.004), glutathione (p = 0.03), carnitine (p = 0.03), creatine (p = 0.001), β‐hydroxybutyrate (p = 0.01), ADP (p = 0.04) and alanine (trend, p = 0.07) were decreased in the ORL/CP D2 tumours when compared to VEH group, whereas no significant changes were observed in the ORL/CP D0 cohort (Fig. 4a). This evidence concerns the gene CP and neoplasm.