MTOR and ovarian cancer: The apoptotic effect of FASN inhibition results from upregulation of the stress response gene DDIT4 (DNA damage‐inducible transcript 4), which negatively regulates the mTOR pathway.40 Yang et al. 19 have also shown in ovarian cancer cells that DDIT4 suppressed mTOR to stimulate orlistat‐induced cell death via caspase‐2 activation.