They protect cells against electrophilic damage via catalysing the conjugation of ROS and glutathione.9, 10 Dysfunction of GSTs has been implicated in the progression of RCC, because of the defect of anti‐oxidant capacity.11 Our study showed that the ROS activity (reflected by DCF immunofluorescence) was highest in ccRCC cells with rs1055259 AA genotype than AG and GG genotypes. Here, HPGDS is linked to nonpapillary renal cell carcinoma.