ENSG00000280371 and neoplasm: CYLD cutaneous syndrome (CCS; synonym Brooke‐Spiegler syndrome – OMIM 605041) is an inherited tumour syndrome arising because of germline mutations in the tumour suppressor gene CYLD. 1 Defined by the rare appendageal tumour cylindroma, patients develop numerous cutaneous tumours, and a minority develop a type of salivary gland tumour, membranous basal cell adenoma, which shares similar histology.