We focused on cytokeratin profiles and compared these with an existing dataset of differentially expressed keratins in inherited CYLD defective tumours from a cohort of 32 tumours (Table S1; see Supporting Information).2 Lung tumours demonstrated a similar transcriptomic cytokeratin profile (including increased expression of KRT13, KRT18 and KRTCAP3) to cutaneous cylindroma (Fig. 3b; Table S1), in addition to other markers in cutaneous cylindroma such as increased NTRK2 (TRKB) and NTRK3 (TRKC) expression (data not shown). This evidence concerns the gene NTRK3 and neoplasm.