AQP4 and focal epilepsy: The patients with multiphasic non-MS disease consisted of five patients who were diagnosed with ADEM-ON, five with NMOSD (AQP4 n = 2, MOG n = 1), four with recurrent ON, two with multiphasic disseminated encephalomyelitis (MDEM) and one with ON followed by seizures (once secondary generalized convulsion, once focal epilepsy) (Fig. 3).