Through comprehensive analysis of expression data from ONCOMINE and TCGA, we found that ERCC1, ERCC2, ERCC4, ERCC5, and DDB2 were differently expressed in CRC and normal tissues; ERCC2, ERCC3, ERCC5, XPA, and DDB2 correlated with clinicopathological parameters of CRC, while ERCC2, ERCC4, and XPC might predict prognosis of CRC. The gene discussed is XPC; the disease is colorectal carcinoma.