In order to elucidate the expression profile and prognostic role of core NER pathway members (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, XPA, XPC, DDB1, and DDB2) in CRC, we performed comprehensive analysis by using available datasets of ONCOMINE and TCGA (The Cancer Genome Atlas). This evidence concerns the gene ERCC5 and colorectal carcinoma.