For colon cancer, ERCC3 high expression was related with better T stage (P = 0.011); increased ERCC5 expression indicated deeper invasion of T stage (P = 0.040) and presence of distant metastasis (P = 0.015); DDB2 high expression suggested earlier TNM stage (P = 0.005) and absence of lymph node (P = 0.020) or distant metastasis (P = 0.012). The gene discussed is ERCC5; the disease is malignant colon neoplasm.