In order to elucidate the expression profile and prognostic role of core NER pathway members (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, XPA, XPC, DDB1, and DDB2) in CRC, we performed comprehensive analysis by using available datasets of ONCOMINE and TCGA (The Cancer Genome Atlas). Here, DDB2 is linked to colorectal carcinoma.