HIF1A and Familial prostate cancer: To further examine this effect, we transfected HIF-1α siRNA into prostate cancer cells and then examined their viability following docetaxel treatment with or without propofol in hypoxic conditions or with docetaxel alone in normoxia; there was little change in the docetaxel resistance among the three groups (Figures 4(a)–4(c), Table 6).