TRIOBP and deafness: In family R1, one reported nonsense mutation c.2581C>T (p.R861X) and a novel frameshift mutation c.3089delC (p.P1030LfsX183) in the TRIOBP gene were found. TRIOBP encodes a filamentous-actin-binding protein that has been identified as the gene for DFNB28 deafness [13].