In conclusion, we presented here novel compound heterozygous mutations in the PARK2 gene, consisting of EX 1‐2 del and a splicing mutation c.619‐1 (G > C) in intron 6 and propose that the mutations were responsible for EOPD in a Chinese family, since other known PD‐related mutations could not be detected. This evidence concerns the gene PRKN and Parkinson disease.