Through the combination with Ox‐LDL, LOX‐1 may cause lots of endothelial dysfunction and would contribute to vascular atherosclerosis, inflammation, acute coronary syndrome and stroke (Chen et al., 2003; Honjo et al., 2003; Inoue, Arai, Kurihara, Kita, & Sawamura, 2005; Inoue et al., 2010). The gene discussed is OLR1; the disease is acute coronary syndrome.