To sum up, considering the roles of NSE, S100B, miR‐210, and miR‐374a in regulating the HIE mechanism, this study assessed their diagnostic performance for HIE among a Chinese population, drawing a conclusion that the synthetic role of NSE, S100B, miR‐210, and miR‐374a could reach a most ideal result regarding HIE diagnosis and prediction of HIE prognosis (i.e., DQ score). The gene discussed is S100B; the disease is perinatal asphyxia.