The hepatotoxicity criteria of this study were quite rigid (elevation of ALT/AST > 3 × ULN or elevated total bilirubin > 2 × ULN, and ALP > 2 times threshold as a significant elevation; the hepatotoxic events were also defined as Hy's Law cases, liver-related treatment discontinuation, hospitalization due to hepatic cause and acute liver failure, transplant, or death). This evidence concerns the gene GPT and acute liver failure.