If the neuropsychiatric effects of EFV are not tolerated, then the patient should be switched to RPV, DTG, lower-dose EFV or NVP (if the CD4+ count is < 250 cells/μL in women or < 400 cells/μL in men; if virologically suppressed, then EFV can be switched to NVP at higher CD4+ counts as this is not associated with increased risk of rash-associated hepatitis), 400 mg daily. The gene discussed is CD4; the disease is Hepatitis.