CD4 and AIDS: Initiation of ART should be deferred until AKI has resolved with creatinine clearly on a downward trend and an eGFR suitable for the selected ART.42 Should a patient have AIDS, CD4 count < 50 cells/μL or severe HIV-related disease such as thrombotic thrombocytopaenic purpura, initiation of ART may be the overriding therapeutic goal even if AKI has not yet resolved.