CD4 and deep vein thrombosis: Many researchers have documented the positive correlation between thrombosis and HIV infection because HIV predisposes to a hypercoagulable state, particularly those with severe immunosuppression (CD4 < 200 cells/mL).13,14 A study conducted in 2009 at Nelson Mandela Hospital, Mthatha, showed that the prevalence of DVT was 12.5% amongst HIV-positive patients admitted to the medical wards.15