The results of the forest plot suggested that among cancer patients with XIST as the oncogenes, digestive system carcinoma patients with gastric cancer, pancreatic cancer or esophageal squamous cell carcinoma showed a shorter OS than non-digestive system carcinoma patients with nasopharyngeal carcinoma or osteosarcoma (digestive system carcinoma, HR = 0.50; 95% CI: 0.37–0.69, p < 0.0001; non-digestive system carcinoma, HR = 0.58; 95% CI: 0.39–0.87, p = 0.008. The gene discussed is XIST; the disease is osteosarcoma.