Other members of the Iroquois (IRO/IRX) family, IRX1, IRX3 and IRX5 have been found differentially methylated [5, 20] and/or expressed [5, 16, 18, 20] between supratentorial and infratentorial PAs, suggesting that these genes may have an important role in specific location cancer development. The gene discussed is IRX3; the disease is cancer.