Then, analyzing by IPA, the list of genes whose CpG loci are differentially methylated between supratentorial vs infratentorial tumors, we identified these pathways: cAMP-mediated signaling; G-Protein Coupled Receptor Signaling; LXR/RXR Activation; Maturity Onset Diabetes of Young (MODY) Signaling; FXR/RXR Activation. The gene discussed is NR1H4; the disease is diabetes mellitus.