IRX2 and neoplasm: In particular, Jeyapalan et al. [20] identified an intergenic CpG site associated to IRX2 that resulted to be differentially methylated between the two tumor groups; whereas we detected a differential methylation of a CpG island that spans the promoter region and part of the gene body of IRX2. In our sample set, IRX2 gene showed a hypermethylation and an expected downregulation in supratentorial PAs compared to the infratentorial PAs (Figure 4A), confirming the gene expression profile observed by the other studies [16, 18, 20].