The colorectal carcinoma cell line KM-12 created in 1988 [13], was later discovered as having an intrachromosomal translocation in chromosome 1 [14] fusing the actin-binding protein, tropomyosin, to the NTRK kinase domain forming a constitutively active TPM3-NTRK1 gene fusion. The gene discussed is TPM3; the disease is colorectal carcinoma.