meso-CART cells secreted high levels of interferon-γ (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-α (TNF-α) in response to mesothelin+ tumor cells (Aspc-1-meso, Skov3-meso, Panc-1-meso, and Capan-2), but not mesothelin- cells (Aspc-1, Skov-3, and Panc-1). Here, TNF is linked to neoplasm.