Moreover, activation of the EGFR pathway has been shown to induce PD-L1 expression, [7, 32] while inhibition of EGFR has been shown to down-regulate expression of PD-L1 in EGFR mutated NSCLC cells, but not in the EGFR WT cells [12, 32]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.