CD274 and non-small cell lung carcinoma: Higher PD-L1 expression is associated with better efficacy of PD-1/PD-L1 therapeutics and improved response in NSCLC, [9, 10] however PD-L1 expression is not the sole determinant of response to PD-1/PD-L1 therapy and some patients who do not express PD-L1 have been shown to respond to PD-1/PD-L1 inhibition [11, 12].