Hence EAI045 may not be an optimal agent to treat all EGFR C797S-related drug-resistant lung cancers, and new agents to inhibit EGFR L858R/T790M/C797S and Del-19/T790M/C797S, ideally without the help of a second agent such as Cetuximab, are needed. This evidence concerns the gene EGFR and lung carcinoma.