Histological evaluation of tissue samples from gastrointestinal neoplasms are commonly carried out by immunohistochemistry (IHC) analysis of target proteins against CDX2 [6], Mucins (MUC2) [7], Special AT-rich sequence binding protein 2 (SATB2) [8], Cytokeratins [9, 10], β-catenin [11], Carcinoembryonic antigen (CEA) [12], and Cadherin 17 [13, 14]. This evidence concerns the gene CEACAM5 and digestive system neoplasm.