PI3K activity is often high in tumors due to the loss of the PTEN tumor suppressor, which allows a constitutive activation of AKT kinase, inappropriate mTORC1 signalling, phosphorylation and inactivation of 4EBP1 and, consequenltly, eIF4E available to be phosphorylated by MNK1. This evidence concerns the gene MKNK1 and neoplasm.