SMAD4 and non-small cell lung carcinoma: Recent studies, mechanistically, demonstrated that SLU7 modulates the splicing and expression of SRSF3 and HNF4α genes, which are essential for the preservation of the hepatocyte identity [34]; amiodarone induces the autophagy-preferential degradation of miR-224 in hepatocellular carcinoma tumorigenesis [16]; increased miR-224, directly targeting the TNFAIP1 and SMAD4 expression, functions as a potent oncogenic miRNA to promote cell migration, invasion, and proliferation in NSCLC [18, 19].