Although we previously demonstrated that galectin-3 overexpression upregulates upstream efflux pump protein and downregulates apoptosis signaling in anti-cancer drug-stimulated Caco2 cells [10], galectin-3 downregulation in phthalate-treated, anti-cancer drug-challenged HCT116 cells suggests a unique regulatory pathway for phthalate-induced drug resistance. Here, LGALS3 is linked to cancer.