After incubation with DYRK1B siRNA or non-specific siRNA at concentrations ranging from 10 to 80 nM for five days, the MTT assay showed that siRNA-mediated knockdown of DYRK1B significantly reduced liposarcoma cell viability in both cell lines in a dose-dependent manner (Figure 2E). This evidence concerns the gene DYRK1B and liposarcoma.