CXCR3 mediates kidney disease in murine lupus nephritis (121, 122), and reduction of the transcription factor FLI1 results in amelioration of kidney disease in MRL/lpr mice with concomitant reduction in CXCR3+ T cells and CXCL9/10 expression (123). The gene discussed is CXCR3; the disease is lupus nephritis.