The accumulation of UV-induced mutations in a recently published HPV38 transgenic skin cancer model that recapitulates hit-and-run carcinogenesis, for example, is unlikely to be caused through an EP300/CREBBP dependent mechanism as no EP300/CREBBP binding has been detected in unbiased AP/MS studies with HPV38 E6 (White et al., 2012a; Viarisio et al., 2018). This evidence concerns the gene EP300 and skin cancer.