Previously, it has been reported that after infection, several classes of pathogens such as Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus pyogenes, and HIF-1α promote killing of pathogens by modulating immune response of the host (Peyssonnaux et al., 2005; Nizet and Johnson, 2009). The gene discussed is HIF1A; the disease is infection.